Low Sperm Count

Most couple see a significant increase in sperm count after taking fertility vitamins, that are specifically formulated for men who have low sperm count.

These are the most important vitamins known to increase sperm count:

CoQ10: This nutrient is a powerful anti-oxidant that is normally present in the male seminal fluids. A lack of CoQ10 causes a wide range of sperm abnormalities like low sperm count, poor motility and morphology.

Glutathione:
Glutathione plays a very important role in protecting sperm from free radical damage and improving sperm motility.

Methylcobalamin:
This is vitamin B12, which studies have shown to treat low sperm count, oligospermia and even absent sperm count or azoospermia.

Vitamin C:
Vitamin C is a very important fertility vitamins and has many functions in treating sperm problems. First and foremost it's a anti-oxidant , and second it makes increases the fluidity of the spermatic fluids preventing sperms from sticking together. Clinical studies have shown that taking 1000 mg of vitamin C twice daily for up to two months. results in increased sperm count and sperm motility.

Source: 
http://www.natural-health-for-fertility.com/how-to-get-pregnant-with-pcos-low-sperm-count.html#.UjfkhcZmhLc

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PubMed Study

 BMC Urol. 2012 Mar 19;12:6. doi: 10.1186/1471-2490-12-6.

Impact of seminal trace element and glutathione levels on semen quality of Tunisian infertile men.

Atig F, Raffa M, Habib BA, Kerkeni A, Saad A, Ajina M.

Source

Unit of Reproductive Medicine, University Farhat Hached Hospital, 4000 Soussa, Tunisia. atigfatma@hotmail.fr

Abstract

BACKGROUND:

Growing evidence indicates that oxidative stress can be a primary cause of male infertility. Non-enzymatic antioxidants play an important protective role against oxidative damages and lipid peroxidation. Human seminal plasma is a natural reservoir of antioxidants. The aim of this study was to determine glutathione (GSH) concentrations, trace element levels (zinc and selenium) and the lipid peroxidation end product, malondialdehyde (MDA), in the seminal plasma of men with different fertility potentials.

METHODS:

Semen samples from 60 fertile men (normozoospermics) and 190 infertile patients (74 asthenozoospermics, 56 oligozoospermics, and 60 teratozoospermics) were analyzed for physical and biochemical parameters. Zinc (Zn) and selenium (Se) levels were estimated by atomic absorption spectrophotometry. Total GSH (GSHt), oxidized GSH (GSSG), reduced GSH (GSHr) and MDA concentrations were measured spectrophotometrically.

RESULTS:

Zn and Se concentrations in seminal plasma of normozoospermics were more elevated than the three abnormal groups. Nevertheless, only the Zn showed significant differences. On the other hand, Zn showed positive and significant correlations with sperm motility (P = 0.03, r = 0.29) and count (P < 0.01, r = 0.49); however Se was significantly correlated only with sperm motility (P < 0.01, r = 0.36). GSHt, GSSG and GSHr were significantly higher in normozoospermics than in abnormal groups. We noted a significant association between seminal GSHt and sperm motility (P = 0.03). GSSG was highly correlated to sperm motility (P < 0.001) and negatively associated to abnormal morphology (P < 0.001). GSHr was significantly associated to total sperm motility (P < 0.001) and sperm count (P = 0.01). MDA levels were significantly higher in the three abnormal groups than in normozoospermics. Rates of seminal MDA were negatively associated to sperm motility (P < 0.01; r = -0.24) and sperm concentration (P = 0.003; r = -0.35) Meanwhile, there is a positive correlation between seminal lipid peroxidation and the percentage of abnormal morphology (P = 0.008).

CONCLUSIONS:

This report revealed that decreased seminal GSH and trace element deficiencies are implicated in low sperm quality and may be an important indirect biomarker of idiopathic male infertility. Our results sustain that the evaluation of seminal antioxidant status in infertile men is necessary and can be helpful in fertility assessment from early stages.

PMID:

 

22429816

 

[PubMed - indexed for MEDLINE] 

PMCID:

 

PMC3349502

 

Free PMC Article

FAQ about PCOS and Glutathione

PCOS is a condition that is rising alarmingly all over the world.

It is the most prevalent reproductive problem in young girls and women, affecting up to 10% in the 15 to 50 age group. Although reaching almost 25% if women with mild cystic ovaries and ovaries damaged by the contraceptive pill are included.

PCOS is generally considered a syndrome rather than a disease, because it manifests through a group of signs and symptoms that can occur in any combination, rather than having one known cause.

Other names for Polycystic Ovary Syndrome are Stein-Leventhal Syndrome, hyperandrogenic chronic anovulation, functional ovarian hyperandrogenism, and Polycystic Ovary Disease.

Source":
Read more: http://www.progesteronetherapy.com/faq-pcos.html#ixzz2f7jyNQy4
Under Creative Commons License: Attribution

Symptoms vary and include some or all of the following...

• oligomenorrhoea (absent or infrequent periods) or amenorrhea (no menstrual period). The normal cycle length is between 21 to 35 days. But in women with PCO the cycle length can vary from every 6 weeks, to only 1 to 8 periods a year, to none at all. Other symptoms include include lengthy bleeding episodes, scant or heavy periods, or frequent spotting. Ovulation would be infrequent or not at all, leading to a drop in progesterone levels
• enlarged ovaries (usually 1.5 to 3 times larger than normal) with a few to many follicles arrested in growth, commonly called...
• cysts (fluid-filled sacs), giving the classic "string of pearls" appearance to ovaries with many cysts. PCOS is difficult to diagnose without the presence of some cysts or ovarian enlargement. Often the underlying cause is inflammation, which would not be picked by the radiographer. Cystic ovaries can lead to...
• chronic pelvic pain - although the exact cause of this pain isn't known, inflammation is the most likely cause. It is considered chronic when it has been noted for greater than six months. But follicles arrested in growth cannot ovulate, which leads to...
• anovulation (lack of ovulation), which is relatively common as the follicles mature only occasionally, this leads to...
• low progesterone levels, as it's only after ovulation that the follicle, now called the corpus luteum, produces progesterone. But low progesterone levels lead to...
• high levels of luteinising hormone (LH) as the pituitary is trying to stimulate ovulation. High LH suppresses follicle stimulating hormone (FSH) so this leads to arrested follicle growth in the next cycle. But LH also stimulates the thecal cells in the ovary to produce androgens which leads to...
• high androgens (hyperandrogenism), particularly high testosterone, androstenedione, and dehydroepiandrosterone sulfate (DHEAS), leading to excess facial and body hair, male pattern baldness, deepening of the voice, weight problems including obesity and a smaller hip to waist ratio, acne, oily skin, dandruff, suppression of ovarian function, leading to anovulation which leads to...
• infertility (the inability to get pregnant within six to 12 months of unprotected intercourse, depending on age) and low progesterone levels
• high blood glucose level is occasionally found, leading to...
• high insulin, this leads to...
• high androgens, anovulation and low progesterone
• A prolonged high insulin level leads to...
• insulin resistance, a condition where the body's use of insulin is inefficient, which in turn can lead to weight gain/obesity, blood glucose problems, acanthosis nigricans (a sign of insulin resistance, these are dark brown, 'velvety' patches found on the neck, armpits, groin, vulva and other areas), skin tags (acrochordons), high androgens, high triglycerides, elevated LDL and reduced HDL cholesterol levels. But this leads to a greater susceptibility to...
• heart disease, which is often associated with...
• hypertension (high blood pressure) and...
• high homocysteine, which is caused by a lack of vitamins B2, 6, 12, folic acid and zinc. But a lack of zinc can lead to...
• acne and a suppressed progesterone level. But heart disease, insulin resistance and malfunctioning ovaries are caused by...
• oxidative stress, which in turn is caused by...
• a lack of antioxidants, which includes zinc, selenium, arginine, N-acetyl cysteine, glutathione, and in particular Vitamin D. But oxidative stress is also caused by...
• high sugar intake and foods which convert to sugar, these are the most oxidizing foods we can eat. It causes glycation, which releases free radicals, damaging cells in the process and leading to...
• inflammation

Source:
Read more: http://www.progesteronetherapy.com/faq-pcos.html#ixzz2f7kYwEst
Under Creative Commons License: Attribution

Polycystic Ovarian Syndrome (PCOS)

Posted in Articles, News

 (PCOS) is a diagnosis that used to be called a “syndrome”. Syndromes are a compilation of symptoms with the absence of absolute diagnostic criteria. The syndrome predominantly revolved around infertility with the presence of cystic ovaries. Along with these criteria were obesity, acne, facial hair, depression, fatigue etc.

PCOS/Insulin Resistance occurs on average in 1 in 15 women and appears to be on the rise. It is the most common endocrine disorder in pre-menopausal women.

This “syndrome” needs to be renamed, as physicians know that the primary defect is NOT in the ovaries and in fact has absolute diagnostic laboratory findings. PCOS is simply insulin resistance diagnosed when women’s FSH/LH levels (blood work) have a shifted ratio. In non-PCOS women, the ratio is 2:1. In PCOS women it is less than this and often grossly shifted to a 1:2 ratio or worse.

Today we know that cysts do NOT have to be present to be accurately diagnosed with PCOS. In fact women who have had their ovaries removed are frequently diagnosed with PCOS. Understanding why some women will get cysts on their ovaries and others do not, identifies why the name is not reflective of the underlying condition anymore.

The culprit in PCOS, is how insulin interacts with the receptor site on cells – nothing more, nothing less. The reason many more symptoms than the ones listed above exist is because insulin interacts with every cell in the body. Insulin is required to carry glucose (sugar) into cells. Insulin levels will increase either immediately or years after receptors become damaged. Stress is a main cause of receptor site changes. Once receptor sites changes have occurred long enough, insulin levels will begin to increase. Not all people with insulin resistance have elevated insulin levels. It depends on when the condition is diagnosed.

Insulin increases an enzyme in the ovary (P450c17 alpha) which can cause cysts. We all have a unique metabolic response. 50% of women will make more insulin in response to the receptor site changes and 50% will not. This is why we have missed more than 50% of insulin resistant women who simply don’t have cysts on their ovaries.

One hormone change triggers another, which changes another. This makes a vicious cycle of out-of-balance hormones. In addition, one receptor change on the cell membrane triggers another, which changes another. Women with insulin resistance often have cortisol resistance, thyroid resistance, progesterone resistance, etc… Once insulin resistance reverses (usually takes six months), response to all hormones improves.

The diagnostic criterion is a laboratory finding that shows abnormal ratios of the pituitary hormones, leutinizing hormone (LH) to follicle stimulating hormone (FSH) as stated above.

Symptoms of PCOS can be one or more of the following yet can be silent for many years

• Tendency to gain weight (10 to 200 pounds)
• Mood swings (anxiety, depression)
• Fatigue
• Acne
• Excess hair growth on face
• Thinning hair
• Irregular menses
• Poor fertility
• Cystic ovaries

Not all patients have all these symptoms. Some patients don’t have any of these symptoms and they just begin to manifest around perimenopause. A telltale sign that PCOS exists in perimenopausal women is when they have an atypical response to BioIdentical Hormone Replacement Therapy by getting acne or not having relief from hormone therapy of current symptoms.

As mentioned earlier, stress is the most common cause to receptor site changes. Poor sleep poor nutrition, habitual caffeine and or alcohol use, synthetic birth control pills, chronic antibiotic use; are some main contributors to stress.

To properly treat PCOS, we have to address cellular health

• Stress triggers must be identified and addressed
• Nutritional Optimization
• Vitamin or Medication use to reverse Insulin Resistance

Treatment

Nutrition

• Gluten Free carbohydrates
• Up to 80 gm/day of carbohydrates (gluten free) in one day
• Protein – at least 90 gm per day
• Eat small amounts of food every 3 hours rather than large, infrequent meals.
• Keep something sweet (hard candy) with you in the event that you feel your blood sugar dropping.

B12 is used for both options. Sublingual (dissolved under the tongue 4 times daily or injections given at home 2-3 times weekly).

Source:
http://www.drramsey.com/polycystic-ovarian-syndrome-pcos-2/


PubMed Study:

DNA damage, DNA susceptibility to oxidation and glutathione level in women with polycystic ovary syndrome.

Dinger Y, Akcay T, Erdem T, Ilker Saygili E, Gundogdu S.

Source

Istanbul University, Cerrahpasa Medical Faculty, Department of Biochemistry, 34300 Turkey.

Abstract

Recent studies have addressed the possibility of an association between polycystic ovaries and ovarian cancer. DNA damage is the first step of the carcinogenesis, and susceptibility to cancer, in general, is characterized by high DNA damage. Free radical-mediated DNA damage and impaired antioxidant defence have been implicated as contributory factors for the development of cancer. This study evaluates DNA damage (strand breakage, base oxidation, formamidopyrimidine DNA glycosylase (Fpg) sensitive sites), H2O2-induced DNA damage, a marker of DNA susceptibility to oxidation and glutathione (GSH) level, a powerful antioxidant, in women with polycystic ovary syndrome (PCOS). Women with PCOS showed a significant decrease in GSH level, a significant increase in DNA strand breakage and H2O2-induced DNA damage. Although Fpg-sensitive sites were higher in the PCOS group compared to the control group, the difference did not reach a statistically significant level. Significant correlations were found between free testosterone and DNA strand breakage (r = 0.46, p<0.01) and free testosterone and H2O2-induced DNA damage (r = 0.41, p<0.05). The data indicate that DNA damage and susceptibility of DNA to oxidative stress are increased in women with PCOS and may explain the association between PCOS and ovarian cancer.

PMID:

16509054

[PubMed - indexed for MEDLINE]

Take the antioxidant amino acids L-arginine and N-acetyl cysteine, studies have shown these restore gonadal function.

The amino acids L-glutamine and L-glycine are very helpful. The brain can use them in place of glucose for energy, so they stop all binging, tiredness, cravings for sugary foods and alcohol. Glutamine also heals the lining of the gut, it boosts the immune system and is the most abundant amino acid in the muscles, so helping with muscle weakness. These two amino acids are also two of the three precursors to glutathione, which apart from vitamin D, is the most important antioxidant the body makes. The third amino precursor is cysteine, which is essential to take

Read more: http://www.progesteronetherapy.com/faq-pcos.html#ixzz2f7lPOsU6
Under Creative Commons License: Attribution

Resveratrol

I compiled studies regarding resveratrol's interactions with other drugs such as plavix, ibuprofen, statins and aspirin. One of Cellgevity's antioxidant ingredient is resveratrol. It is advised then to people who are taking these drugs mentioned above to choose Max GXL or Max One for their glutathione dietary supplement or stop these drugs if they would like to take the Cellgevity.

A natural compound concentrated in the skins of red grapes, seasonal berries and some Asian herbs, resveratrol has received increasing attention as a possible breakthrough in treating age-related illnesses like cancer and heart disease. Laboratory animals given high doses of the compound show longer lifespans, resistance to developing the physiological problems associated with consuming high-fat diets and resistance to the tumor-causing effects of certain toxins. According to the Mayo Clinic, the health benefits of resveratrol in humans are unknown and under clinical scrutiny. 

Read more: http://www.livestrong.com/article/234349-health-warnings-for-resveratrol/#ixzz2f7c2PUr1

Increased Side Effects from Cardiovascular Drugs

As counterintuitive as it sounds, use of resveratrol supplements might actually be contraindicated in individuals suffering from heart disease. Resveratrol impairs the activity of an important liver enzyme responsible for breaking down a number of medications prescribed to treat aspects of heart disease or diabetes, including statins, which lower cholesterol, and sildenafil (i.e., Viagra), which is used to treat erectile dysfunction co-occurring with poor blood circulation. As such, the side effects associated with these prescription drugs become augmented in the presence of resveratrol. Because it decreases blood thickening, resveratrol might also inadvertently augment the side effects of yet other prescribed heart drugs such as Plavix, used to inhibit clots on the walls of blood vessels that feed the heart, and aspirin, sometimes used to facilitate blood thinning. Taking resveratrol along with Plavix or aspirin might lead to excess bleeding.

Read more: http://www.livestrong.com/article/234349-health-warnings-for-resveratrol/#ixzz2f7cGUUtF

HOW MUCH TO TAKE OF RESVERATROL?

As an antioxidant, resveratrol can help protect your cells from damage caused by free radicals in your body. Increasing your intake of resveratrol, which is found naturally in red wine, may improve the overall health of your heart and can guard this vital organ against disease. Despite this key medicinal benefit, more clinical research is needed to understand how resveratrol works in the human body and what dosage of this antioxidant is necessary to elicit positive health effects.

Read more: http://www.livestrong.com/article/411598-how-much-to-take-of-resveratrol/#ixzz2f7cWK1QD

Grapes, as well as certain other plants, produce resveratrol as a self-defense response to damage, disease or other stress. This compound develops primarily in the grape skin. Red wine contains more resveratrol than white wine because the grape skins remain on longer during the process of making red wine. While drinking moderate amounts of red wine may benefit your health, counting milligrams of resveratrol may not be worth your time.

Recommended Resveratrol Dosage

Because resveratrol isn't an essential nutrient, no required amount exists. Animal studies suggest as much as 500 mg daily may be necessary to provide any health benefits. Red wine contains at most 12.59 mg resveratrol per liter, so to get 500 mg daily, you'd need to drink almost 40 liters of wine daily. A 40 mg daily dose of resveratrol may also have some benefits, showed a study published in the "Journal of Clinical Endocrinology and Metabolism" in June 2010. Even if a 40 mg daily dose is sufficient, you'd still need to drink a little over 3 liters of wine daily to get that much resveratrol.

Read more: http://www.livestrong.com/article/411745-how-much-red-wine-do-you-need-to-get-enough-resveratrol/#ixzz2f7dKyLQV

Medication Interactions

Treatment with resveratrol supplements may not be appropriate if you're taking certain medications. Do not take resveratrol if you're taking an anticoagulant, such as heparin, warfarin, ibuprofen or aspirin. This treatment combination may increase your risk of experiencing bruising or bleeding complications. In addition, avoid using resveratrol in conjunction with medications that are broken down by your liver, such as fexofenadine, lovastatin and itraconazole. Resveratrol may reduce the rate at which your liver metabolizes these drugs, which can increase your likelihood of experiencing medication-specific side effects.

Read more: http://www.livestrong.com/article/411598-how-much-to-take-of-resveratrol/#ixzz2f7crabYm

Safe Amounts of Wine

Drinking any alcohol in moderation may have some health benefits, including a 20 to 30 percent lower risk of coronary artery disease, note experts from Oregon State University. Too much alcohol carries health risks, though, so most health experts advise a limit of two drinks daily for men and one drink daily for women. That works out to 10 oz. of wine daily for men and 5 oz. of wine daily for women. If you're pregnant or have a heart condition, avoid alcohol altogether.

Resveratrol for Health

As an antioxidant, resveratrol helps protect cells from damage by free radicals, which are potentially harmful atoms and molecules that occur naturally in the environment. Results of test tube and animal studies suggests resveratrol may raise HDL, or good, cholesterol, protect blood vessels from damage, prevent blood clots and reduce risk of diabetes, notes MayoClinic.com. It may also inhibit the growth of cancer cells. No evidence shows conclusively that resveratrol reduces risk of coronary heart disease or cancer, however.

Sources of Resveratrol

The richest sources of resveratrol are red wines, which average between 1.98 and 7.13 mg resveratrol per liter. The next best source is Spanish red grape juice, which contains 1.14 to 8.69 mg resveratrol per liter, even more than most rose or white wines. Fresh red grapes and boiled peanuts are also relatively rich sources of resveratrol, but they contain significantly less of this compound than does red wine. On average, resveratrol dietary supplements contain between 10 to 50 mg resveratrol.

Read more: http://www.livestrong.com/article/411745-how-much-red-wine-do-you-need-to-get-enough-resveratrol/#ixzz2f7dZ9sGU

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Our Toxic World and Declining Fertility In this modern life, we are surrounded by a sea of chemicals that are having devastating effects on our delicate hormonal balance and reproductive systems. We are exposed to toxins in our food, water supply and environment that create oxidative stress within our cells and can negatively impact our fertility. Infertility is now estimated to affect one in six couples.

"There is no question that environmental toxins have a negative effect on the immune responses. This area has been under study for many years through the National Institutes of Health... I am amazed when I see perfectly healthy, trim males who are producing mutant sperm of the kind I did not see years ago. Is this a warning that we are exposed to a degree that is damaging us? Yes I have great fears. 

The increasing population of the planet is not due to humankind's ability to reproduce with ease; it is because people are surviving longer due to improved hygiene and disease control. In reality, human fertility, particularly in industrialised nations, is on the decrease. Fewer babies are being born and more couples are resorting to fertility treatment. Worldwide, over 400 million tons of synthetic chemicals are produced annually."    Dr Alan E. Beer (quote from page 237 'Is your body baby friendly?')

Glutathione and Fertility

Environmental toxins and oxidative stress affect sperm quality in males and ovarian function in females. 

Glutathione (GSH) is essential for male and female reproductive health. Glutathione is the body's "Master Antioxidant" and is able to neutralise the oxidative damage caused by harmful free radicals and eliminate toxins from the body. 

Studies have demonstrated that depleted glutathione levels may be linked with infertility and pregnancy complications. 

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Depleted Glutathione Affects Sperm Quality

There is growing evidence that oxidative stress is a primary cause of male infertility.  Decreased glutathione levels have been shown to be linked with poor sperm quality. 

Glutathione is also the essential molecule that allows the sperm to bind to the egg at conception.
(Note: It takes 60 days for new sperm to become fully mature, so any glutathione supplement regime must be continued for at least three months to improve male fertility.)  

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Low Glutathione Levels Decrease Egg Quality

Human ovum

Every month the ovaries create around 10 - 20 follicles which house immature eggs. Usually only one of these follicles goes on to create a fully mature egg which has the potential to be fertilised by a sperm.

Studies have shown that low concentrations of glutathione in the follicle may affect the egg's ability to be fertilised. 

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Glutathione and Pregnancy

The role of antioxidants like folic acid in preventing birth defects like spina bifida is well known, but the role of the master antioxidant Glutathione (GSH) in pregnancy is often overlooked.

In addition to playing an important role in fertility and conception, glutathione plays an important role in the development and growth of the baby. Glutathione helps to regenerate stores of other antioxidants like Vitamin C and E. It also protects both mother and baby from the damaging effects of free-radicals and oxidative stress.

Many pregnancy complications and birth defects have been linked to oxidative stress, free radical damage and low glutathione levels in the mother and baby. The role of glutathione in the development of the baby and placenta is crucial.

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Glutathione Protects the Foetus

The foetus is highly sensitive to chemicals (pollution, toxins, heavy metals, drugs, etc) and the human placenta possesses a significant amount of glutathione to help detoxify these chemicals during the critical period of organ development in the baby.

Environmental and lifestyle factors are known to cause oxidative stress and lower glutathione levels – resulting in birth defects, abortion and miscarriages in pregnancy. Glutathione can decrease the incidence of birth defects and also minimise the oxidative stress that occurs during labour and the birth process.

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Toxic Relief

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The Ultimate Antioxidant

In his book "Toxic Relief" Dr Colbert discusses the importance of glutathione supplementation, and recommends Cellgevity™ as the "best anti-aging, best detoxifier, best anti-inflammatory and best antioxidant supplement available".

By boosting the cellular production of glutathione, Cellgevity™ is able to help us detoxify our cells and eliminate harmful heavy metals and toxins from our bodies. 

Cellgevity™ contains the powerful glutathione precursor RiboCeine™, which dramatically boosts glutathione production in the body.  Cellgevity™ also contains selenium, which has been shown to be vital for fertility and supporting a healthy pregnancy. Synergistic antioxidants, anti-inflammatories and the purest plant extracts such as curcumin and resveratrol also provide optimal fertility support, making Cellgevity ideal for fertility support.

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"Research has shown that over a period of 14 months, women who took nutritional supplements conceived earlier than those who did not. Studies also indicate that nutritional supplements such as antioxidants, multivitamins and amino acids can help balance hormones, encourage egg production and improve sperm quality."   Dr Alan Beer (p. 270 "Is your body baby friendly?")

Sources:

http://www.cellgevity4life.com/fertility.html

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