Friday, 20 September 2013

Diabetes and Glutathione

Diabetes mellitus is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. Prolonged high blood sugar levels can cause serious complications.

Antioxidants are very Important in Diabetes

Glutathione is the body's most powerful antioxidant, and has many positive benefits in people with diabetes and impaired glucose tolerance. Glutathione has been shown to improve insulin sensitivity in diabetics.

Clinical trials have demonstrated the therapeutic effects of antioxidants to reduce insulin resistance. Dr Lester Packer discusses the importance of glutathione in his bookAntioxidants in Diabetes Management:

“Administration of glutathione was found to be advantageous in type 2 diabetics and those with impaired glucose tolerance (iGT). Glutathione improved insulin secretion in patients with iGT. Glutathione also improves insulin sensitivity in patients with type 2 diabetes after acute and chronic administration.”

Oxidative Stress and Diabetes

Reeds et al, 2002

Glutathione status is closely tied to the progression and severity of diabetes. People with poorly controlled diabetes often have significant depletion of blood glutathione levels. Many of the complications of diabetes are linked to oxidative damage due to the elevated blood sugar levels.

Complications that may arise as a result include damage to the large and small blood vessels ("peripheral vascular disease"); diabetic retinopathy; kidney disease; nerve damage ("neuropathy"); skin problems; dental problems; and increased risk of infection due to a weakened immune system.

As the body's "master antioxidant", glutathione helps to reduce oxidative stress and its consequences. Research studies have shown that supplementation with glutathione precursors may help to reduce oxidant induced diabetic complications such as those shown below.

Diabetic retinopathy can lead to blindness

Up to 25% of diabetics develop foot problems due to reduced blood circulation or damaged nerves.

Diabetes can affect the microcirculation in the kidney

Diabetes Affects the Blood Circulation

Unhealthy red blood cells as seen under the microscope, sticking together in "Rouleaux" or stacks.

In a toxic environment, red blood cells stick together and form"Rouleaux" or stacks. This is a very unhealthy state and increases the risk of many diseases. Rouleaux formation occurs in diabetes and is one of the reasons diabetics develop peripheral vascular disease and diabetic retinopathy. Rouleaux formation is also seen in patients with infections, multiple myeloma, inflammatory diseases and cancer.

When red blood cells stack together, it is often an indication of inflammation in the body. Glutathione has powerful antioxidant and anti-inflammatory effects and also improves the endothelial function of blood vessels. Increasing glutathione levels helps the red blood cells to circulate more freely and transport oxygen more effectively.

Normal red blood cells circulating freely

Cellgevity™ is a powerful antioxidant and anti-inflammatory supplement, designed to support your entire glutathione and cellular defence systems. Powered by RiboCeine™ and a blend of the purest plant extracts, Cellgevity dramatically increases glutathione production in every cell of the body.

Alpha Lipoic Acid Can Lower Blood Sugar

Antioxidants in Diabetes, L.Packer

Alpha lipoic Acid is a sulphur containing fatty acid that your body requires to convert sugar into energy.

Dr Packer discusses the beneficial effect of alpha lipoic acid in his book Antioxidants in Diabetes Management.

Alpha-lipoic acid (ALA) can help lower blood sugar levels in diabetes and reduce complications.

Research has shown that ALA can improve insulin sensitivity and significantly decrease symptoms of diabetic neuropathy.

Alpha lipoic acid is one of the many powerful natural ingredients in the glutathione boosting supplement Cellgevity™.

Nutrition and Exercise Are Important Too

Dr Don Colbert, author of Reversing Diabetes, discusses natural ways to beat the disease. In addition to glutathione supplementation, he stresses the importance of good nutrition and exercise:

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Source: http://www.cellgevity4life.com/diabetes.html

Visible Solutions™ Advanced Skin Care Technology

Visible Solutions skincare products contain the exclusive Amino-Nutrient Complex™ and the following specialised ingredients:

Terra-Pure™ Aloe
The patented reverse osmosis processing of the Aloe in our products ensures that all the amino acids and vitamins, etc., retain their full efficacy. Just our Aloe alone, without any other ingredient, would give you collagen support. Additionally, this special Aloe base, when mixed with other ingredients in our products, ensures that these critical nutrients can penetrate your skin, delivering them where they are needed most.

Antarcticine®
A naturally derived glycol protein that helps to prevent dryness of the skin and also serves to protect the epidermis from extreme cold. Studies have shown that Antarcticine optimizes production of collagen I, collagen IV, and elastin.

Relistase™
An active peptide that enhances skin elasticity and tightness. It is especially targeted at mature skin with studies showing significant increases in elastin in as little as four weeks of regular use.

Lipochroman-6
A highly potent antioxidant that helps protect the skin from photo-aging. It is shown to be more effective than Resveratrol, Vitamin E and ferulic acid in protecting against oxidative stress. It has also been shown to have greater antioxidant power than Vitamin E and C, grape seed extract and other well-known antioxidants.

The Visible Solutions advanced skin care pack contains:

One Minute Wonder ~ This refreshing gel will gently exfoliate dead skin without any harsh abrasives.
Youth Recovery Serum ~ This nutrient intensive serum helps firm and smooth the face and neck area and revitalises skin texture. The serum allows rapid delivery of the Amino-Nutrient complex and natural plant extracts to maintain a youthful appearance. Protects skin from environmental stresses.
Eye Rescue ~ This light weight eye cream is specifically designed to hydrate the fine lines and dark circles around the delicate eye area. Can also be used on the lips to make them smooth and soft.
Skin Brightening Mousse ~ This luxurious day cream is designed to brighten the appearance of skin, diminish enlarged pores and uneven skin tone. The slow release of alpha hydroxy acids makes it ideal for sensitive skin.
Replenishing Cream ~ This rich hydrating night repair formula will deeply moisturise the skin and diminish visible lines and wrinkles. The Max Amino-Nutrient Complex helps maintains elasticity and tone.

SCOTT NAGASAWA’S ANSWERS TO THE SEVEN BIGGEST QUESTIONS ABOUT GLUTATHIONE

For his presentation during the Max It! Convention, Dr. Scott Nagasawa presented on the seven biggest questions regarding glutathione. To share this insight, we’ve reproduced a summarized version of his talk here.

What are free radicals?
Free radicals are molecules that have an extra or missing electron. This makes them unstable and can damage other cells if they’re not neutralized. While some free radicals come from normal metabolic process, more can be introduced by environmental stimulus: unhealthy diets, infections, stress, pollution, industrial chemicals, and more. Too many free radicals in our system can damage our cells and lead to cell death, DNA mutation, cancer, and premature aging.

How do we protect our bodies against free radicals?
Our bodies have a natural antioxidant defense system that can be supported by supplementing it with the right materials. Vitamin C and E are antioxidants that we get through food. Our bodies also naturally produce antioxidants such as Alpha Lipoic Acid, CoQ10, and glutathione. Finding ways to promote more production of these natural antioxidants will go a long way to keeping our bodies healthy.

What is Oxidative Stress?
Oxidative Stress occurs when our antioxidant defense force is overwhelmed by too many free radicals. This can happen as a result of an excess in energy production, inflammation, toxins, radiation, and drugs. This can have serious effects as over 75 diseases and disorders have been associated with Oxidative stress.

Why is glutathione considered the Master Antioxidant?
Glutathione is not only the most abundant naturally produced antioxidant, it has a multifunctional role. As an Antioxidant, it’s made up of glutamic acid, cysteine, and glycine, and it’s one of the few that’s found in the mitochondria in our bodies. It acts as a detoxifier and an immune system enhancer. Unlike other antioxidants, glutathione can recycle itself and can also recycle other antioxidants such as Vitamin C and E.

Why is detoxification important?
The accumulation of waste and toxins causes problems for the body, so detoxification is an important removal of foreign compounds. This detoxification breaks down these invaders into water soluble pieces that can be passed through the kidneys. While important, this detoxification can lead to glutathione depletion.

What role does glutathione play in detoxification?
Glutathione attaches to these toxins to create a glutathione complex that is easier to detoxify and more water soluble. Glutathione therefore plays an essential role in removing many of these toxins from our system. Unfortunately, our levels of glutathione decrease as we age, a problem that is compounded by environmental toxins and pollutants, radiation, medication and more.

What is the background of RiboCeine’s Development?
The need to effectively increase glutathione levels through supplementation led to RiboCeine’s development. Thanks to a joint development of the University of Minnesota and the VA Medical Center, 25 years of research led to the development of this amazing technology. By focusing on how to improve liver glutathione levels, the research team discovered that by attaching Cysteine to Ribose, they could provide a way to give cysteine safe passage through the stomach, a process that was once considered impossible. After being broken up in the lower GI tract, RiboCeine releases the ribose to help with ATP production and the cysteine to aid in glutathione production.

There are now currently 20 published studies that have researched the effectiveness of RicoCeine. As more and more doctors and scientist witness the power of RiboCeine, we become even more confidant that Dr. Nagasawa’s technology is the future.

Chronic Pain, Inflammation and the Role of Glutathione

Acute pain is the body's response to an injury - it is a normal and necessary part of the healing process as it alerts us that something is wrong and encourages us to rest and recover. However, chronic pain is a debilitating condition that can go on for months or years, and results from cellular inflammation and damage to the delicate nerve endings that transmit pain.

Cellular inflammation results from the accumulation of free radicals inside our cells. Toxins and heavy metals can also accumulate and damage the cells. The body requires antioxidants to clean up these harmful free radicals and toxins, and no antioxidant is more important than Glutathione, our Master Antioxidant.

Unfortunately, our glutathione levels become rapidly depleted as we age, leading to a build up

of free radicals and inflammation within our cells. To add to the problem, pain medications and

other pharmaceutical drugs have the unfortunate side effect of further depleting our glutathione

levels, creating a vicious circle.

Glutathione is a Potent Anti-Inflammatory

In addition to being our most powerful antioxidant, glutathione also has potent anti-inflammatory properties. Glutathione helps to reduce the levels of inflammatory cytokines (such as NFKb, TNF and C Reactive Protein), as explained by Dr Don Colbert. Curcumin also has powerful anti-inflammatory properties, and has been compared to Celebrex in scientific studies.

Cellgevity™ is an advanced antioxidant and anti-inflammatory nutritional supplement that has been clinically proven to significantly boost glutathione levels in the body. Cellgevity contains RiboCeine™ to fuel glutathione production, along with other natural glutathione enhancing ingredients such as selenium, and natural anti-inflammatory plant compounds such as curcumin (derived from turmeric).

An Anti-Inflammatory Diet is Important Too

A number of factors influence inflammation in the body and diet is one of the most important inflammation modulators. An anti-inflammatory diet is useful in helping to control chronic pain, including plenty of vegetables (especially sulphur rich vegetables like broccoli, garlic, asparagus, etc) and healthy oils (extra virgin coconut oil). Processed and sugary foods are best avoided as they create more inflammation.

Many cooking oils are very pro-inflammatory (vegetable oil, canola oil, soybean oil), as are the

toxic transfats contained in fast foods (burgers, fries, store bought cakes etc). The ubiquitous

transfats are some of the worst disease causing agents in the modern diet. Partially hydrogenated

oils or 'transfats' do not occur naturally so the body is unable to process them, which stresses

the liver and creates a very inflammatory response.

Virgin coconut oil on the other hand has potent anti-inflammatory effects and has many other

health benefits. Fish oils are high in beneficial Omega 3 fats which also help to reduce inflammation.

Other factors such as reducing stress, getting enough sleep, and moderate exercise can also help

to lower inflammation.

Source: http://www.cellgevity4life.com/chronic-pain.html

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Cardiovascular Disease

Cardiovascular disease remains the biggest cause of deaths worldwide.
The risk factors for cardiovascular disease have traditionally been considered age, high cholesterol, smoking, family history, poor diet and a lack of exercise.

More recently doctors are realising the importance of underlying inflammation and oxidative stress, and are using blood levels of inflammatory markers (eg C reactive protein) to predict coronary risk.

What your doctor may not tell you

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In his book What your doctor may not tell you about heart disease (see extract to the right), Dr Mark Houston explains thatlow glutathione levels are a strong predictor of a possible heart attack. A lack of gluathione has been associated with increased free radical and oxidative damage.

Oxidative stress is now recognised as a key event in the development of atherosclerosis. An initial oxidative injury to a blood vessel triggers the artery to form a cholesterol cap over the area of injury. Over time, this can build up into a fatty plaque which can grow large enough to stop the flow of blood. Thrombus (blood clot) can form over the plaque and break off, blocking supply to blood to vital organs such as the brain (resulting in a stroke) or heart (resulting in a heart attack). Since oxidative injury is the first step in cardiovascular disease, it makes sense that sufficient antioxidant defence is required to stop the damage.

High blood pressure (hypertension) is perhaps the most commonly experienced symptom of cardiovascular disease. High blood pressure occurs when the blood vessels become stiff and constricted. A strong link has been found between high blood pressure and low glutathione levels. Increasing glutathione levels helps the body to deal with oxidative stress and also assists the blood vessels to become more vasodilated (relaxed), due to an increase in available nitric oxide (NO) in the endothelium.

Increasing glutathione levels will:

Lower blood pressure
Reduce the risk of heart attack
Improve immune function
Decrease inflammation
Improve vascular health
Protect cells from the damaging effects of free radicals
Slow the oxidation of fats
Assist with the uptake of other antioxidants

Latest News in Cardiology Journal links low Glutathione levels to increased Heart Attack Risk:

Cellgevity™ provides your cells with unique patented nutrients that have been clinically shown to raise cellular glutathione levels more effectively than any other supplement.

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Source: http://www.cellgevity4life.com/cardiovascular.html

Glutathione is the body's most powerful antioxidant and plays a key role in the prevention of cancer

Glutathione (GSH) performs a number of vital roles to keep cells functioning optimally. Free radicals are now known to contribute to virtually every degenerative disease including cancer. Glutathione neutralises these harmful free radicals and helps to slow the aging process. Glutathione also chelates heavy metals and eliminates toxins, protects cells against radiation damage, and supports a healthy immune system.Unfortunately many factors conspire to reduce the body's vital glutathione stores, including chronic illness, aging, stress, environmental toxins and chemotherapy.

Glutathione supplementation beneficial after chemotherapy

Low glutathione levels are commonly found among those undergoing chemotherapy. A glutathione supplement is thought to be very beneficial after a course of chemotherapy, to restore glutathione levels.

Research scientists Bogliun et al (see abstract opposite) studied women with ovarian cancer who were being treated with chemotherapy. Some of the women were also treated with intravenous glutathione. Those given the glutathione not only had fewer toxic side effects from the chemotherapy but also had better overall survival rates.

Glutathione: A bullet proof vest?

According to Patrick Holford, author of Say No To Cancer: ‘Glutathione deserves attention as it is perhaps the most important antioxidant within cells and has proven to be highly cancer protective.’

The anti-cancer properties of glutathione are well documented. In 1981 a group of scientists gave a group of rats a known carcinogen, then treated half of the rats with glutathione. After eight months there were no survivors in the control group, but 81% of the rats that had received glutathione were still alive.

Glutathione has been shown to stimulate apoptosis (cell death) of malignant cells while leaving healthy cells unaffected. Glutathione also regulates levels of tumour necrosis factor alpha (TNF1), an important immune modulator involved in cell death.

Ultimate Glutathione Enhancement

Glutathione is a fragile molecule that cannot be taken orally as it is quickly broken down in the digestion. Instead the necessary glutathione precursors must be provided.
Cellgevity™ is a unique nutritional supplement that contains a special combination of natural glutathione precursors designed to increase production of glutathione in the body.

Research studies highlighting the importance of glutathione in cancer:

What is Parkinson's Disease?

Parkinson’s occurs when certain nerve cells (neurons) in a part of the brain called the substantia nigra die or become impaired. Normally, these cells produce a vital chemical known as dopamine. Dopamine allows smooth, coordinated function of the body's muscles and movement. When approximately 70% of the dopamine-producing cells are damaged, the symptoms of Parkinson disease appear. These symptoms include tremor, muscle rigidity or stiffness, and slowness of movement.

The Glutathione Connection

The disease process in Parkinson's patients creates extreme oxidative stress within the brain. Glutathione is the brain's most powerful antioxidant that helps protect cells from oxidative stress and neutralise toxins. However glutathione is known to be depleted in the brains of people with Parkinson's disease.

Doctors have observed what has been called the "glutathione miracle" when patients with severe Parkinson's disease given intravenous glutathione experience a rapid improvement in symptoms.

Glutathione is depleted in Parkinson's

Patients with Parkinson's Disease have significantly depleted levels of glutathione in their brains.

“Loss of intracellular neuronal glutathione (GSH) is an important feature of neurodegenerative disorders including Parkinson's disease. The consequences of GSH depletion include increased oxidative damage to proteins, lipids, and DNA and subsequent cytotoxic effects.”
(Ref: Free Radical Biology and Medicine)

Glutathione Supplementation

Scientists have demonstrated that glutathione supplementation may help to slow the progression of brain disorders such as Parkinson's disease.

However, glutathione cannot be supplemented orally as it is a fragile molecule that is broken down in the digestive system if taken by mouth. Instead glutathione precursors must be provided so that the cells can manufacture glutathione. Breakthrough compound RiboCeine™ effectively delivers these essential precursor nutrients to the cells where they can then be turned into glutathione.

RiboCeine is far more effective than any other form of glutathione enhancement and is uniquely found in the supplement Cellgevity™. Cellgevity is ideal for supporting brain function, improving mental clarity, improving sleep, increasing energy and for optimising overall health.

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Sources: http://www.cellgevity4life.com/parkinsons.html