Friday 20 September 2013

Cardiovascular Disease

Cardiovascular disease remains the biggest cause of deaths worldwide.
The risk factors for cardiovascular disease have traditionally been considered age, high cholesterol, smoking, family history, poor diet and a lack of exercise. 


More recently doctors are realising the importance of underlying inflammation and oxidative stress, and are using blood levels of inflammatory markers (eg C reactive protein) to predict coronary risk. 

What your doctor may not tell you

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In his book What your doctor may not tell you about heart disease (see extract to the right), Dr Mark Houston explains thatlow glutathione levels are a strong predictor of a possible heart attack. A lack of gluathione has been associated with increased free radical and oxidative damage. 

 

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Oxidative stress is now recognised as a key event in the development of atherosclerosis. An initial oxidative injury to a blood vessel triggers the artery to form a cholesterol cap over the area of injury. Over time, this can build up into a fatty plaque which can grow large enough to stop the flow of blood. Thrombus (blood clot) can form over the plaque and break off, blocking supply to blood to vital organs such as the brain (resulting in a stroke) or heart (resulting in a heart attack).  Since oxidative injury is the first step in cardiovascular disease, it makes sense that sufficient antioxidant defence is required to stop the damage. 
High blood pressure (hypertension) is perhaps the most commonly experienced symptom of cardiovascular disease. High blood pressure occurs when the blood vessels become stiff and constricted. A strong link has been found between high blood pressure and low glutathione levels. Increasing glutathione levels helps the body to deal with oxidative stress and also assists the blood vessels to become more vasodilated (relaxed), due to an increase in available nitric oxide (NO) in the endothelium. 




Increasing glutathione levels will: 

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  • Lower blood pressure
  • Reduce the risk of heart attack
  • Improve immune function
  • Decrease inflammation
  • Improve vascular health
  • Protect cells from the damaging effects of free radicals 
  • Slow the oxidation of fats
  • Assist with the uptake of other antioxidants

Latest News in Cardiology Journal links low Glutathione levels to increased Heart Attack Risk:

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